Investigating the causes of seizures in temporal lobe epilepsy
Official title: Temporal lobe epileptogenesis
Funded at Stanford University · NIH-11070313 · Data updated 2026-11-12
This study is looking at how certain brain cells might be linked to seizures in people with temporal lobe epilepsy, using animal models to find out if losing these cells affects how often seizures happen, with the hope of discovering new ways to help reduce or stop seizures for those who suffer from this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $494,239 |
| NIH project number | 5R01NS136433-02 |
| Project ID | NIH-11070313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who experience frequent seizures.
✕Less likely to help
Patients with other forms of epilepsy or those who do not have temporal lobe epilepsy may not benefit from this research.
What this research studies
This research aims to uncover the underlying causes of seizures in patients with temporal lobe epilepsy by studying specific brain cells known as reelin-positive interneurons in the dentate gyrus. The project will utilize animal models, including pilocarpine-treated rats and sea lions, to observe the correlation between the loss of these interneurons and seizure frequency. Advanced techniques such as continuous video-EEG monitoring and various cellular recording methods will be employed to gather data on the function and loss of these neurons. The ultimate goal is to identify potential therapeutic targets to prevent or reduce seizures in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce or prevent seizures in patients with temporal lobe epilepsy.
How similar studies have gone: Previous research has shown promise in understanding seizure mechanisms through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Buckmaster, Paul S. — Stanford University
- Study coordinator: Buckmaster, Paul S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.