Investigating the causes of meningioma tumors and potential treatments
Official title: Understanding druggable drivers of meningioma tumorigenesis
Funded at University of California, San Francisco · NIH-10892127 · Data updated 2026-11-12
This study is looking at how meningioma brain tumors work, especially in older adults and African Americans, to find new ways to treat them with targeted drugs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $535,724 |
| NIH project number | 5R01CA262311-04 |
| Project ID | NIH-10892127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults, women, and African American individuals diagnosed with meningioma.
✕Less likely to help
Patients with other types of brain tumors or those not diagnosed with meningioma may not benefit from this research.
What this research studies
This research focuses on understanding the biological mechanisms behind meningioma tumors, which are common brain tumors, particularly in older adults and African American patients. The team is using advanced molecular profiling techniques on a large number of meningioma samples to identify different subgroups of these tumors and their unique characteristics. They are also developing innovative models to test new drug therapies, specifically targeting the CDK4/6 proteins that may drive tumor growth. By exploring these pathways, the research aims to find effective pharmacologic treatments for meningioma patients.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for meningioma patients, improving treatment options and outcomes.
How similar studies have gone: Other research has shown promise in targeting similar pathways in different tumor types, suggesting potential for success in this novel approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Raleigh, David R — University of California, San Francisco
- Study coordinator: Raleigh, David R
Related research
Other NIH-funded projects on the same topics.
-
Meningioma biology and new therapies guided by molecular profiling
A large, multi-institution study is exploring how meningiomas grow and respond to treatment, using advanced molecular profiling to find safer, more effective ways to manage them.
-
Biomarker-based guidance to predict meningioma outcomes and radiotherapy response
A gene-based test is being developed to help predict how meningioma tumors will behave and how patients may respond to radiotherapy.
-
Meningioma radiotherapy response: understanding gene clues and how to tailor treatment
A short research project will study why some meningioma tumors respond differently to radiotherapy by looking at gene activity and how it affects treatment outcomes.
-
Genomic and biochemical clues behind meningioma race differences and outcomes
This grant aims to uncover biological and environmental factors that cause differences in meningioma occurrence and treatment results across racial groups, with the goal of improving care for patients affected by this brain tumor.
-
How the MN1 protein drives aggressive acute myeloid leukemia
This project looks at how the MN1 protein and its partner BAF complex keep leukemia genes active in people with acute myeloid leukemia to reveal new treatment targets.
-
How meningiomas change over time and new treatment targets
This project looks for molecular signs that predict which meningiomas will come back and finds drug targets to help people with aggressive or recurrent tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.