Investigating the causes of meningioma tumors and potential treatments
Understanding druggable drivers of meningioma tumorigenesis
This study is looking at how meningioma brain tumors work, especially in older adults and African Americans, to find new ways to treat them with targeted drugs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10892127 on NIH RePORTER |
What this research studies
This research focuses on understanding the biological mechanisms behind meningioma tumors, which are common brain tumors, particularly in older adults and African American patients. The team is using advanced molecular profiling techniques on a large number of meningioma samples to identify different subgroups of these tumors and their unique characteristics. They are also developing innovative models to test new drug therapies, specifically targeting the CDK4/6 proteins that may drive tumor growth. By exploring these pathways, the research aims to find effective pharmacologic treatments for meningioma patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults, women, and African American individuals diagnosed with meningioma.
Not a fit: Patients with other types of brain tumors or those not diagnosed with meningioma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for meningioma patients, improving treatment options and outcomes.
How similar studies have performed: Other research has shown promise in targeting similar pathways in different tumor types, suggesting potential for success in this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Raleigh, David R — University of California, San Francisco
- Study coordinator: Raleigh, David R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.