Investigating the causes of inflammatory macrophage development in a serious immune condition
Defining signals contributing to inflammatory hemophagocyte differentiation in TLR7 mediated Macrophage Activation Syndrome
This study is looking at how certain immune cells called macrophages get activated and cause problems in people with Macrophage Activation Syndrome (MAS), using a mouse model that simulates a related condition, to help find out what triggers these cells and how they might lead to symptoms like anemia and low platelet counts.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10897181 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain immune cells, specifically macrophages, become activated and contribute to a severe condition known as Macrophage Activation Syndrome (MAS). By using a mouse model that mimics aspects of systemic lupus erythematosus, the study aims to identify the signals that lead to the differentiation of inflammatory macrophages. The research will explore the relationship between these macrophages and the development of symptoms like anemia and low platelet counts, which are critical in MAS. The findings could provide insights into the mechanisms of this condition and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with rheumatic diseases or viral infections that may lead to Macrophage Activation Syndrome.
Not a fit: Patients without rheumatic diseases or viral infections, or those not experiencing symptoms related to MAS, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from Macrophage Activation Syndrome and related inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding macrophage differentiation and its implications in inflammatory diseases, suggesting that this approach has potential for success.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Thulin, Natalie K — University of Washington
- Study coordinator: Thulin, Natalie K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.