Investigating the causes of early pregnancy loss using stem cell models
Multispecies investigation of early pregnancy loss mechanisms using bioengineered stem cell models
This study is looking into why many early pregnancies end in loss by using special lab models to see how certain signals affect embryo development, and it’s designed to help anyone interested in understanding more about early pregnancy and what might go wrong.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11084279 on NIH RePORTER |
What this research studies
This research aims to understand the mechanisms behind early pregnancy loss, which affects nearly 60% of human conceptions. By utilizing bioengineered stem cell models, the study will explore how specific signaling pathways, particularly WNT/β-catenin, influence the development of the embryo during the critical implantation phase. The research will compare these processes across different mammalian species to identify unique aspects of human embryonic development. This approach addresses significant gaps in knowledge that have hindered progress in understanding pregnancy loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced recurrent pregnancy loss or are undergoing fertility treatments.
Not a fit: Patients who are not planning to conceive or those with no history of pregnancy loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for early pregnancy loss.
How similar studies have performed: While there has been research on pregnancy loss, this specific approach using bioengineered stem cell models to compare species is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Abel, Ashley — Yale University
- Study coordinator: Abel, Ashley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.