Investigating the causes of disabilities in multiple sclerosis by focusing on specific brain cells and differences between sexes.
Neurodegeneration Underlying Distinct Disabilities in Multiple Sclerosis Using a Cell-Specific, Region-Specific, and Sex-Specific Approach
This study is looking at how brain changes in multiple sclerosis can cause different disabilities, and it’s for anyone affected by MS, as researchers want to find new ways to help improve their lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11078723 on NIH RePORTER |
What this research studies
This research aims to understand how neurodegeneration in multiple sclerosis (MS) leads to various disabilities by examining specific brain cells, regions, and the influence of sex. The study will utilize a combination of clinical observations and preclinical models, including male and female mice, to explore how different brain areas are affected in MS. By employing advanced techniques like MRI and RNA sequencing, researchers will identify potential treatment targets that could help repair disabilities associated with MS. The findings will be translated back to clinical trials tailored for both men and women.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing distinct disabilities related to walking, vision, cognition, or coordination.
Not a fit: Patients with other neurological conditions or those without significant disabilities related to multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments that specifically address the diverse disabilities experienced by MS patients.
How similar studies have performed: Previous research has shown promise in targeting specific cell types in the central nervous system for neurodegenerative diseases, suggesting that this approach could yield valuable insights for MS as well.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Voskuhl, Rhonda R — University of California Los Angeles
- Study coordinator: Voskuhl, Rhonda R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.