Investigating the causes of delayed neurological deficits after brain hemorrhage.
Role of Microthrombi and Inflammation in Delayed Deficits after SAH
This study is looking into why some people have delayed brain problems after a type of brain bleed called aneurysmal subarachnoid hemorrhage, focusing on how tiny blood clots and inflammation might affect recovery, and it’s using mice to find clues that could help improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10987060 on NIH RePORTER |
What this research studies
This research focuses on understanding why some patients experience delayed neurological deficits after suffering from an aneurysmal subarachnoid hemorrhage (aSAH). It examines the role of microthrombi and inflammation in the brain, which may contribute to these deficits occurring 4-10 days post-hemorrhage. By using a mouse model, the researchers aim to explore how these factors affect brain blood flow and lead to neurological decline. The study will analyze the presence of inflammatory markers and blood clots in the brain to identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have survived an aneurysmal subarachnoid hemorrhage and are at risk of developing delayed neurological deficits.
Not a fit: Patients who have not experienced an aneurysmal subarachnoid hemorrhage or those with pre-existing neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce neurological deficits in patients recovering from aSAH.
How similar studies have performed: Previous research has indicated that inflammation and microthrombi play a role in neurological deficits after brain injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Mcbride, Devin William — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Mcbride, Devin William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.