Investigating the causes of congenital obstructive uropathy and its variations
Official title: Human genetic studies to solve the etiology of congenital obstructive uropathy and its subphenotypes
Funded at Columbia University Health Sciences · NIH-11144684 · Data updated 2026-11-12
This study is looking at the genetic causes of kidney and urinary tract problems, especially congenital obstructive uropathy, to help improve care and support for families affected by these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $360,836 |
| NIH project number | 1R56DK138164-01A1 |
| Project ID | NIH-11144684 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include expectant parents whose fetuses have been diagnosed with congenital obstructive uropathy or related kidney anomalies.
✕Less likely to help
Patients with congenital kidney anomalies that are not obstructive in nature may not receive benefit from this research.
What this research studies
This research focuses on congenital anomalies of the kidney and urinary tract, particularly congenital obstructive uropathy (COU), which can lead to severe health issues in affected individuals. The study aims to identify genetic factors contributing to these conditions, enhancing our understanding of their etiology. By utilizing advanced genetic testing and analysis, the research seeks to improve prenatal care, risk assessment, and management strategies for families impacted by COU. Ultimately, the goal is to provide better prognostic information and support for patients and their families.
Why it matters
Potential benefit: If successful, this research could lead to improved prenatal care and management strategies for families affected by congenital obstructive uropathy.
How similar studies have gone: Previous research has shown promise in understanding genetic factors related to congenital anomalies, suggesting potential for success in this area as well.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Sanna-Cherchi, Simone — Columbia University Health Sciences
- Study coordinator: Sanna-Cherchi, Simone
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.