Investigating the causes of complex lymphatic anomalies.
Official title: “Two-hit” model for lymphatic malformations.
Funded at Ut Southwestern Medical Center · NIH-11025398 · Data updated 2026-11-12
This study is looking at rare lymphatic conditions caused by unusual growth of lymph vessels, and it's using a special mouse model to see how certain gene changes, especially in the KRAS gene, might affect these conditions, with the goal of finding better and safer treatments for people dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $508,436 |
| NIH project number | 1R01HL176788-01 |
| Project ID | NIH-11025398 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with complex lymphatic anomalies, particularly children and young adults.
✕Less likely to help
Patients with lymphatic anomalies that do not involve genetic mutations in the KRAS gene may not benefit from this research.
What this research studies
This research focuses on complex lymphatic anomalies (CLAs), which are rare conditions caused by abnormal development of lymphatic vessels. The team is using a novel mouse model to study how specific genetic mutations, particularly in the KRAS gene, affect the formation of lymphatic malformations. By understanding the mechanisms behind these anomalies, the researchers aim to identify new and safer treatment options for patients suffering from CLAs. The study will explore how these genetic changes interact with environmental factors to influence lymphatic development.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for patients with complex lymphatic anomalies.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in lymphatic anomalies, but this specific approach using a two-hit model is relatively novel.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Dellinger, Michael Thomas — Ut Southwestern Medical Center
- Study coordinator: Dellinger, Michael Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.