Investigating the causes of chronic beryllium disease and its immune responses
Using Multi-Omics to Define Regulators and Drivers of Granulomatous Inflammation and Chronic Beryllium Disease
This study is looking at how the immune system responds to beryllium exposure, which can cause chronic beryllium disease, and it invites patients to help by sharing samples to better understand the inflammation and lung issues that can arise from this exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10992597 on NIH RePORTER |
What this research studies
This research aims to understand how the immune system reacts to beryllium exposure, leading to chronic beryllium disease (CBD). By examining specific cell types and their regulatory networks, the study will identify key drivers of inflammation and granuloma formation in the lungs. The approach combines genetic and epigenetic analyses to uncover risk factors and pathogenic pathways associated with CBD and its precursor, beryllium sensitization. Patients may contribute to this research by providing biological samples that help elucidate these complex immune responses.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals with a history of beryllium exposure, particularly those showing signs of beryllium sensitization or chronic beryllium disease.
Not a fit: Patients without any history of beryllium exposure or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of chronic beryllium disease, potentially informing better treatment strategies.
How similar studies have performed: Previous research has shown success in understanding immune responses in other environmentally induced diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Maier, Lisa a — National Jewish Health
- Study coordinator: Maier, Lisa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.