Investigating the causes of bladder injury from BK polyomavirus in children after bone marrow transplants
Viral and host predictors of BK polyomavirus associated hemorrhagic cystitis
This study is looking at how a virus called BK polyomavirus can cause painful bladder problems in kids and young adults who have had a bone marrow transplant, with the hope of finding ways to help those affected feel better and prevent these issues in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10876333 on NIH RePORTER |
What this research studies
This research focuses on understanding how BK polyomavirus infection leads to hemorrhagic cystitis, a painful bladder condition, in children and young adults who have undergone bone marrow transplantation. The study aims to identify the viral and host factors that contribute to this complication, which affects a significant number of transplant recipients. By analyzing urine samples and patient responses, the research seeks to uncover mechanisms behind bladder injury and improve patient outcomes. The ultimate goal is to pave the way for effective antiviral therapies and better risk assessment for those at high risk of developing this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults who have undergone allogeneic hematopoietic cell transplantation and are experiencing symptoms related to BK polyomavirus infection.
Not a fit: Patients who have not undergone bone marrow transplantation or are not infected with BK polyomavirus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for children suffering from hemorrhagic cystitis due to BK polyomavirus.
How similar studies have performed: While there is ongoing research into BK polyomavirus, this particular investigation into the mechanisms of bladder injury is novel and aims to fill significant gaps in current understanding.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Laskin, Benjamin Lewis — Children's Hosp of Philadelphia
- Study coordinator: Laskin, Benjamin Lewis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.