Investigating the causes of alpha-gal red meat allergy
Understanding alpha-gal red meat allergy
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11061101
This study is looking into what causes alpha-gal red meat allergy, which can make some people very sick after eating certain meats, and it aims to find out if genes or things like tick bites play a role, so we can help those affected manage their allergy better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11061101 on ClinicalTrials.gov |
What this research studies
This research aims to understand the mechanisms behind alpha-gal red meat allergy, a severe allergic reaction that can occur after consuming mammalian products. It focuses on identifying whether genetic factors or external influences, such as tick bites, contribute to the development of this allergy. By utilizing advanced techniques like single-cell RNA sequencing, the study will analyze immune responses in individuals affected by this allergy, providing insights into how the body reacts to certain foods. The findings could lead to better management strategies for those at risk of anaphylaxis.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 65 and older who have experienced allergic reactions to red meat or mammalian products.
Not a fit: Patients who do not have a history of allergic reactions to red meat or related products may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of alpha-gal red meat allergy, potentially reducing the risk of severe allergic reactions in affected individuals.
How similar studies have performed: Previous research has shown promising results in understanding food allergies, but the specific focus on alpha-gal allergy and its mechanisms is relatively novel.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COMMINS, SCOTT PALMER — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: COMMINS, SCOTT PALMER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.