Investigating the causes of AF10-rearranged leukemias in children and adults
Molecular Pathogenesis of AF10-Rearranged Leukemias
This study is looking at the genetic changes in a type of leukemia that affects children, with the goal of finding better and safer treatments that can help kids fight cancer more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11055387 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular changes associated with AF10-rearranged leukemias, which are a significant cause of cancer in children. The team aims to identify specific genetic alterations and signaling pathways that contribute to these types of leukemia. By analyzing data from a large cohort of pediatric patients, the researchers hope to develop targeted therapies that can effectively eliminate cancer cells while minimizing side effects. This work addresses the urgent need for safer treatment options for pediatric leukemia patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults diagnosed with AF10-rearranged acute myeloid leukemia or T-cell acute lymphoblastic leukemia.
Not a fit: Patients with leukemias that do not involve AF10 rearrangements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that are more effective and less toxic for children and adults with AF10-rearranged leukemias.
How similar studies have performed: Previous research has shown promise in targeting specific genetic alterations in leukemias, indicating that this approach could be successful.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Deshpande, Aniruddha J. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Deshpande, Aniruddha J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.