Investigating the causes and treatments for Type 2 diabetes in children and adolescents
Official title: Understanding and Targeting the Pathophysiology of Youth-onset Type2 Diabetes
Funded at Children's Hospital of Los Angeles · NIH-11036344 · Data updated 2026-11-12
This study is looking at how Type 2 diabetes affects kids and teens, aiming to find out who is most at risk and what factors play a role, so we can help prevent it; we're inviting around 3,750 young people from different backgrounds to join us for regular check-ups to gather important health information.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | February 21, 2023 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $705,245 |
| NIH project number | 5U01DK134984-03 |
| Project ID | NIH-11036344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents with obesity and a family history of Type 2 diabetes.
✕Less likely to help
Patients who do not have obesity or a family history of Type 2 diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the aggressive nature of Type 2 diabetes (T2D) in children and adolescents, aiming to identify those at highest risk and the factors that contribute to the disease. The study will recruit a diverse national cohort of approximately 3,750 children, assessing their health and environmental exposures over time. By examining how these factors vary across different sexes and ethnicities, the research seeks to develop models that can predict T2D risk and inform prevention strategies. Participants will undergo bi-annual assessments to gather comprehensive data on obesity, family history, and other relevant health indicators.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and prevention strategies for Type 2 diabetes in young populations, ultimately reducing health complications and costs.
How similar studies have gone: Previous longitudinal studies on obesity and diabetes in children have shown success, indicating that this approach has a strong foundation.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Goran, Michael Isaac — Children's Hospital of Los Angeles
- Study coordinator: Goran, Michael Isaac
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.