Investigating the causes and treatments for subretinal fibrosis in eye diseases
Official title: Mechanistic study and therapeutic development for subretinal fibrosis
Funded at Tulane University of Louisiana · NIH-11010402 · Data updated 2026-11-12
This study is looking into how certain cells in the eye contribute to a condition called subretinal fibrosis, which can cause serious vision loss, especially in people with age-related macular degeneration, to find new ways to help prevent or treat this problem.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $435,204 |
| NIH project number | 5R01EY034571-03 |
| Project ID | NIH-11010402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with age-related macular degeneration or other conditions leading to subretinal fibrosis.
✕Less likely to help
Patients with non-retinal related conditions or those without any signs of subretinal fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding subretinal fibrosis, a condition that can lead to severe vision loss in diseases like age-related macular degeneration. It aims to explore the cellular and molecular mechanisms behind fibrosis, particularly the role of myofibroblasts and various cell types involved in this process. By studying how these cells contribute to the formation of excessive connective tissue, the research seeks to identify potential therapeutic targets for better treatment options. Patients may benefit from insights that could lead to new interventions for managing or preventing vision loss associated with retinal diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce vision loss in patients with age-related macular degeneration and other retinal diseases.
How similar studies have gone: While the mechanisms of subretinal fibrosis are being actively explored, this research aims to provide novel insights that could lead to breakthroughs in treatment.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Wang, Shusheng — Tulane University of Louisiana
- Study coordinator: Wang, Shusheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.