Investigating the causes and treatments for pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia.
Understanding and targeting molecular and cellular events responsible for pulmonary arteriovenous malformation development, growth and regression
This study is looking into how certain genetic and cellular factors cause abnormal blood vessel connections in people with hereditary hemorrhagic telangiectasia (HHT), with the hope of finding new ways to prevent or treat these issues and improve health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10915604 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and cellular mechanisms that lead to pulmonary arteriovenous malformations (PAVMs) in patients with hereditary hemorrhagic telangiectasia (HHT). By exploring how these abnormal connections between arteries and veins develop, the study aims to identify potential therapeutic targets that could prevent or reverse the growth of PAVMs. The research will utilize advanced imaging techniques and animal models to investigate the underlying biology of these malformations, which could lead to more effective treatments. Patients may benefit from insights gained into the disease process and potential new therapies that could improve their health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with hereditary hemorrhagic telangiectasia who experience pulmonary arteriovenous malformations.
Not a fit: Patients without hereditary hemorrhagic telangiectasia or those who do not have pulmonary arteriovenous malformations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse the progression of pulmonary arteriovenous malformations, significantly improving patient quality of life.
How similar studies have performed: While there has been some research on arteriovenous malformations, this study aims to explore novel mechanisms and therapeutic targets that have not been extensively tested before.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Spiekerkoetter, Edda Frauke — Stanford University
- Study coordinator: Spiekerkoetter, Edda Frauke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.