Investigating the causes and potential treatments for neurodegenerative diseases.
La Spada Outstanding Investigator Award
This study is looking at how certain genetic changes can lead to neurodegenerative diseases like spinal and bulbar muscular atrophy and Huntington's disease, and it aims to find new treatments that could help people with these conditions feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11074038 on NIH RePORTER |
What this research studies
This research focuses on understanding neurodegenerative diseases, particularly those caused by genetic mutations such as the expansion of CAG repeats in the androgen receptor gene. The principal investigator has over 30 years of experience in this field and has made significant discoveries related to spinal and bulbar muscular atrophy (SBMA) and Huntington's disease. The research employs advanced methodologies, including the use of selective PPARd agonists to counteract neurotoxicity in models of these diseases. Patients may benefit from insights into new therapeutic approaches that target the underlying mechanisms of these conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with spinal and bulbar muscular atrophy or Huntington's disease.
Not a fit: Patients with neurodegenerative diseases not related to CAG repeat expansions or those with other unrelated conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the quality of life for patients with neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in neurodegenerative diseases, indicating that this approach could lead to meaningful advancements.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: La Spada, Albert R — University of California-Irvine
- Study coordinator: La Spada, Albert R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.