Investigating the cancer-causing effects of 1,4-Dioxane on the liver.
Project 1 - Toxicity and Liver Carcinogenicity of 1,4-Dioxane: Single Chemical and Mixtures Studies
This study is looking into how 1,4-Dioxane, a chemical sometimes found in drinking water, might increase the risk of liver cancer, especially for people living near contaminated areas, so we can better protect everyone’s health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10868584 on NIH RePORTER |
What this research studies
This research focuses on understanding the potential cancer-causing effects of 1,4-Dioxane, a contaminant found in drinking water, particularly for those living near contaminated sites. The study aims to explore how exposure to 1,4-Dioxane, both alone and in combination with other chemicals, may lead to liver cancer. By conducting experiments with varying concentrations of 1,4-Dioxane in animal models, researchers will identify the mechanisms of toxicity and the specific populations that may be more vulnerable to its effects. The findings could help establish better safety standards for drinking water.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living near Superfund sites or areas with known 1,4-Dioxane contamination.
Not a fit: Patients who do not live near contaminated sites or who have no exposure to 1,4-Dioxane are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety standards for drinking water, reducing the risk of liver cancer in affected populations.
How similar studies have performed: Previous studies have indicated potential carcinogenic effects of 1,4-Dioxane, but this research aims to provide more definitive mechanistic insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Chen, Ying — Yale University
- Study coordinator: Chen, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.