Investigating the brain's extracellular space and its impact on neuron function
CRCNS: The diffusional complexity of the brain's extracellular space
This study is looking at how the space around brain cells changes as we age and how that affects the way brain cells communicate with each other, using special imaging tools and computer models to get a closer look.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10908313 on NIH RePORTER |
What this research studies
This research aims to explore the complexity of the extracellular space (ECS) in the brain at a very detailed level using advanced imaging techniques and computer modeling. By combining experimental methods with computational analysis, the study will assess how the ECS affects the diffusion of neurotransmitters, which are crucial for neuron communication. The research will involve live brain tissue samples to measure the structure and properties of the ECS, focusing on how these factors change with age. This could provide insights into how neuronal signaling is influenced by the ECS's characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with neurological conditions that may be influenced by neurotransmitter signaling.
Not a fit: Patients with conditions unrelated to neuronal function or those who are not experiencing neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to improved treatments for neurological disorders.
How similar studies have performed: While the approach of using super-resolution imaging and computational modeling is innovative, similar studies have shown promise in understanding brain function and neurotransmitter dynamics.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Santamaria, Fidel — University of Texas San Antonio
- Study coordinator: Santamaria, Fidel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.