Investigating the brain changes in a specific type of frontotemporal lobar degeneration.
Official title: Anatomic, Pathologic, and Molecular Signatures of FTLD-TDP type C
Funded at Northwestern University at Chicago · NIH-11052715 · Data updated 2026-11-12
This study is looking at how a specific type of brain condition called TDP-C affects language and thinking skills, and it's for people who have this condition to help us understand the changes in their brains better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $786,632 |
| NIH project number | 1R01AG091388-01 |
| Project ID | NIH-11052715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with frontotemporal lobar degeneration, particularly those exhibiting symptoms related to language and cognitive function.
✕Less likely to help
Patients with other forms of dementia or neurodegenerative diseases that do not involve TDP-C may not benefit from this research.
What this research studies
This research focuses on frontotemporal lobar degeneration with transactive response DNA-binding protein type C (TDP-C), which primarily affects the anterior temporal lobe of the brain. It aims to understand the unique patterns of brain changes associated with TDP-C and how these changes impact language comprehension and other cognitive functions. The study will analyze a large cohort of patients with TDP-C, utilizing advanced imaging techniques and detailed clinical assessments to uncover the molecular and anatomical signatures of the disease. By expanding the scope beyond primary progressive aphasia, the research seeks to explore various clinical manifestations of TDP-C and their effects on brain circuitry.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for patients with frontotemporal lobar degeneration.
How similar studies have gone: Previous research on frontotemporal lobar degeneration has shown promising results in understanding its pathology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Gefen, Tamar D — Northwestern University at Chicago
- Study coordinator: Gefen, Tamar D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.