Investigating the bone marrow environment in myelofibrosis
Official title: Understanding and targeting bone marrow microenvironment in myelofibrosis
Funded at Columbia University Health Sciences · NIH-10755697 · Data updated 2026-11-12
This study is looking at how the environment in the bone marrow affects primary myelofibrosis, a serious blood condition, and aims to find new treatments that could help improve outcomes for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $563,550 |
| NIH project number | 5R01HL155868-04 |
| Project ID | NIH-10755697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with primary myelofibrosis who have limited treatment options.
✕Less likely to help
Patients with other forms of blood disorders or those who are not diagnosed with myelofibrosis may not benefit from this research.
What this research studies
This research focuses on understanding how the bone marrow microenvironment contributes to primary myelofibrosis (PMF), a serious blood disorder that can lead to leukemia. The study aims to explore the interactions between leukemia stem cells and the fibrotic niche in the bone marrow, which is crucial for the disease's progression. By identifying key mediators of fibrosis and testing new therapeutic strategies, including the combination of JAK inhibitors with targeted treatments, the research seeks to improve patient outcomes. Patients may have the opportunity to participate in trials that explore these novel therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with myelofibrosis, potentially improving survival rates and quality of life.
How similar studies have gone: Previous research has shown promise in targeting the bone marrow microenvironment in other hematological conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Ding, Lei — Columbia University Health Sciences
- Study coordinator: Ding, Lei
Related research
Other NIH-funded projects on the same topics.
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Strategies to deplete myelofibrosis stem cells using HDM2/p53 pathway
A patient-focused program tests a therapy that may selectively reduce disease-causing blood stem cells in people with myelofibrosis.
-
Megakaryocyte changes in myelofibrosis and its progression to leukemia
A scientist-guided project will study how abnormal megakaryocytes and signals like TGF-β and IL-13 may drive progression from myelofibrosis toward acute leukemia, with potential implications for future treatments.
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Molecular clues and new therapies for myelofibrosis and related blood cancers
This grant supports research to understand what drives myelofibrosis and related disorders and to develop new treatment ideas for patients.
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Myelofibrosis and the bone marrow environment: how inflammation changes blood production
A doctor-researcher is studying how inflammation in the bone marrow affects the blood-forming system in people with myeloproliferative neoplasms (MPNs) to find ways to prevent scarring and leukemia.
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Early detection of treatment response in myelofibrosis using a new imaging technology
A new, quick imaging method could tell patients with myelofibrosis early whether a treatment is working.
-
MYC-driven vulnerability in myelofibrosis could guide new therapies
A new project is exploring how the MYC protein contributes to myelofibrosis and whether it can be targeted to help people with this blood cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.