Investigating the best ventilation practices for critically ill children with severe respiratory issues
2/2 PROSpect: Prone and Oscillation Pediatric Clinical Trial (DCC)
This study is looking at the best ways to help kids with serious breathing problems by trying out different breathing support methods and positions to see which works best for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10687083 on NIH RePORTER |
What this research studies
This research focuses on improving ventilation strategies for children suffering from pediatric acute respiratory distress syndrome (PARDS), a serious condition affecting many young patients. The trial will compare different methods of ventilation, including traditional mechanical ventilation and high-frequency oscillatory ventilation, as well as the effects of positioning (supine vs. prone) on patient outcomes. Conducted across 45 pediatric intensive care units, the study aims to gather data from up to 1000 children to determine the most effective treatment approaches. By utilizing a randomized controlled trial design, the research will adapt based on the responses observed in the initial participants.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-17 years who are diagnosed with severe pediatric acute respiratory distress syndrome.
Not a fit: Patients who do not have severe PARDS or are outside the age range of 0-17 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved ventilation practices that enhance recovery and survival rates for critically ill children with severe PARDS.
How similar studies have performed: Previous research has shown varying results regarding ventilation strategies in pediatric patients, making this trial a significant effort to establish clearer guidelines.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wypij, David — Boston Children's Hospital
- Study coordinator: Wypij, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.