Investigating the best ventilation methods for critically ill children with respiratory distress
1/2 PROSpect: Prone and Oscillation Pediatric Clinical Trial (CCC)
This study is looking at different ways to help kids with severe breathing problems, called ARDS, by trying out various methods of using breathing machines and positions to see which works best for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10677528 on NIH RePORTER |
What this research studies
This research focuses on improving ventilation practices for children suffering from acute respiratory distress syndrome (ARDS). It involves a clinical trial where pediatric patients will be randomly assigned to different ventilation strategies, including positioning (supine vs. prone) and types of mechanical ventilation (conventional vs. high-frequency oscillatory). The trial will take place in multiple pediatric intensive care units across the U.S. and internationally, aiming to gather specific data on the effectiveness of these methods in treating severe pediatric ARDS. By analyzing outcomes, the research seeks to establish evidence-based practices for managing this critical condition in young patients.
Who could benefit from this research
Good fit: Ideal candidates for participation are children under 21 years old who are experiencing severe pediatric acute respiratory distress syndrome and require mechanical ventilation.
Not a fit: Patients who do not have severe pediatric acute respiratory distress syndrome or are not requiring mechanical ventilation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved ventilation strategies that enhance recovery and outcomes for critically ill children with respiratory distress.
How similar studies have performed: Previous research has shown varying results regarding ventilation strategies in adult populations, but this specific approach in pediatric patients is novel and aims to fill a significant gap in existing knowledge.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Curley, Martha Aq — University of Pennsylvania
- Study coordinator: Curley, Martha Aq
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.