Investigating the best treatment for infants with opioid withdrawal syndrome

Neonatal Treatment Trial

NIH-funded research Children's Hosp of Philadelphia · NIH-10916554

This study is looking at the best medications to help newborns who are going through withdrawal from opioids, and by joining in, families can help improve care for these little ones.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionChildren's Hosp of Philadelphia NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-10916554 on NIH RePORTER

What this research studies

This research focuses on Neonatal Opioid Withdrawal Syndrome (NOWS), a condition affecting infants exposed to opioids. The study will compare the effectiveness of three commonly used medications to determine the best pharmacological treatment for these infants. By participating in this trial, families can contribute to understanding how to improve care for newborns experiencing withdrawal symptoms. The research will take place across multiple centers, ensuring a diverse patient population and robust data collection.

Who could benefit from this research

Good fit: Ideal candidates for participation are infants aged 0-4 weeks who are diagnosed with Neonatal Opioid Withdrawal Syndrome.

Not a fit: Patients who are not diagnosed with NOWS or are older than 4 weeks may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment protocols for infants suffering from opioid withdrawal, enhancing their health outcomes.

How similar studies have performed: Previous research has indicated variability in treatment outcomes for NOWS, suggesting that this comparative effectiveness approach could yield significant insights.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.