Investigating the best timing for clamping the umbilical cord in newborns with heart defects
Official title: 2/2 CORD-CHD: Clamp OR Delay among neonates with Congenital Heart Disease
Funded at George Washington University · NIH-11062355 · Data updated 2026-11-12
This study is looking at how waiting a little longer to clamp the umbilical cord after birth might help newborns with congenital heart disease by improving their health and development, and it’s especially important because we want to find the best care for these high-risk babies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $572,349 |
| NIH project number | 5U24HL166799-03 |
| Project ID | NIH-11062355 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with congenital heart disease who are undergoing delivery.
✕Less likely to help
Patients without congenital heart disease or those who are not newborns may not benefit from this research.
What this research studies
This research focuses on the timing of umbilical cord clamping in newborns diagnosed with congenital heart disease (CCHD). It aims to compare the effects of early cord clamping (within 30 seconds of birth) versus delayed cord clamping (waiting 1-2 minutes) on health outcomes. By conducting a randomized controlled trial, the study will assess how these different practices impact blood transfer from the placenta to the newborn and their subsequent health, particularly regarding iron levels and neurodevelopment. This research is crucial as previous studies have not included high-risk newborns like those with CCHD, leaving a gap in knowledge about the best practices for their care.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes for newborns with congenital heart disease by identifying the optimal cord clamping method.
How similar studies have gone: Previous studies have shown the benefits of delayed cord clamping in healthy newborns, but this research is novel as it specifically addresses high-risk newborns with congenital heart disease.
Where this research is happening
-
George Washington University
Washington, United States Active
Researchers
- Principal investigator: Rice, Madeline Murguia — George Washington University
- Study coordinator: Rice, Madeline Murguia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.