Investigating the best glucocorticoid treatments for vocal fold disease
Official title: Molecular mechanisms underlying optimal glucocorticoid therapy for vocal fold disease
Funded at New York University School of Medicine · NIH-10840435 · Data updated 2026-11-12
This study is looking at different types of medications called glucocorticoids to find out which ones can help heal vocal fold injuries by reducing inflammation and preventing scarring, so that people with voice problems can recover better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 11, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $211,875 |
| NIH project number | 5R21DC021054-02 |
| Project ID | NIH-10840435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from vocal fold disease who may benefit from glucocorticoid therapy.
✕Less likely to help
Patients with vocal fold disease who are not candidates for glucocorticoid treatment or those with other underlying conditions may not benefit from this research.
What this research studies
This research aims to identify which glucocorticoids (GCs) can effectively balance anti-inflammatory and fibrotic gene expression in models of vocal fold injury. By studying how different types and concentrations of GCs affect gene expression in vocal fold fibroblasts, the researchers hope to determine the optimal treatment regimen. This could lead to improved healing outcomes for patients with vocal fold disease, reducing inflammation while preventing excessive scarring that can impair voice function.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for vocal fold disease, enhancing healing and preserving vocal function.
How similar studies have gone: Other research has shown promise in optimizing glucocorticoid therapies for various conditions, suggesting potential success for this approach in vocal fold disease.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Garabedian, Michael J. — New York University School of Medicine
- Study coordinator: Garabedian, Michael J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.