Investigating the best fluid treatment for children with septic shock
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This study is looking at how to better help kids with septic shock by comparing two types of IV fluids to see which one works best and is safer for them when they first get treated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11129293 on NIH RePORTER |
What this research studies
This research focuses on improving treatment strategies for children suffering from septic shock, a severe condition caused by infections leading to organ dysfunction. The study aims to compare two types of intravenous fluids—normal saline and balanced fluids—to determine which is more effective and safer for initial resuscitation in pediatric patients. By analyzing outcomes from fluid administration, the research seeks to fill a critical knowledge gap in pediatric emergency care. The findings could lead to better treatment protocols that enhance recovery and reduce complications for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with septic shock and require emergency treatment.
Not a fit: Patients who are not experiencing septic shock or are outside the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and recovery outcomes for children experiencing septic shock.
How similar studies have performed: Previous adult studies have shown that balanced fluids can reduce adverse kidney events and mortality, indicating potential for similar benefits in pediatric populations.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Balamuth, Frances B — Children's Hosp of Philadelphia
- Study coordinator: Balamuth, Frances B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.