Investigating the anti-cancer effects of tocotrienols in colon cancer
Official title: Anti-cancer effects of tocotrienols and a carboxychromanol in an innovative colon cancer model
Funded at Purdue University · NIH-11049194 · Data updated 2026-11-12
This study is looking at new ways to help prevent colorectal cancer for people with certain genetic mutations and growths in the colon, by testing a form of vitamin E and another compound to see if they can stop cancer cells from growing and reduce inflammation, offering a safer alternative to common pain relievers like aspirin.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $74,517 |
| NIH project number | 5R03CA283236-02 |
| Project ID | NIH-11049194 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who have a history of adenomas or carry specific cancer driver mutations.
✕Less likely to help
Patients without a history of colorectal cancer risk factors or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing new preventive agents against colorectal cancer (CRC), particularly for individuals with cancer driver mutations and adenomas. The study explores the effects of tocotrienols, a form of vitamin E, and a specific metabolite on inhibiting cancer cell growth and inflammation associated with CRC. By targeting the 5-lipoxygenase enzyme and other inflammatory pathways, the research aims to identify effective alternatives to traditional NSAIDs like aspirin, which have limitations due to side effects. The approach involves testing these compounds in innovative colon cancer models to assess their efficacy.
Why it matters
Potential benefit: If successful, this research could lead to new preventive treatments that significantly reduce the risk of colorectal cancer in high-risk populations.
How similar studies have gone: Previous research has shown promising results with tocotrienols in inhibiting cancer growth, indicating potential for success in this novel approach.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Jiang, Qing — Purdue University
- Study coordinator: Jiang, Qing
Related research
Other NIH-funded projects on the same topics.
-
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A new project will use advanced chemical analysis to find blood- and tissue-based markers that indicate colon cancer and its progression.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.