Investigating the 5'-GUAC- RNA sequence and its biological roles
Official title: Exploring the 5'-GUAC- sequence as an important RNA-motif
Funded at University of Colorado Denver · NIH-11090499 · Data updated 2026-11-12
This study is looking at a specific part of RNA called the 5'-GUAC- sequence to see how it works with other RNA strands, which could help us understand its role in health and diseases, including inherited disorders.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | May 16, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $78,000 |
| NIH project number | 5R03AI185538-02 |
| Project ID | NIH-11090499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inherited disorders linked to RNA motifs or those affected by viral infections.
✕Less likely to help
Patients with conditions unrelated to RNA motifs or those not affected by viral RNA are unlikely to benefit from this research.
What this research studies
This research focuses on understanding the 5'-GUAC- RNA sequence motif, which plays a crucial role in various biological processes. The study will explore how this sequence interacts with its complementary strands and its implications in different types of RNA, including viral RNA and micro-RNA. Using advanced biophysical techniques, the researchers aim to uncover the structural changes associated with this motif and its potential relevance to inherited disorders. The findings could provide insights into the biological functions of RNA motifs and their importance in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of RNA-related disorders and inform the development of new therapeutic strategies.
How similar studies have gone: While this specific investigation is novel, similar studies on RNA motifs have shown promising results in understanding their biological significance.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Resendiz, Marino Je — University of Colorado Denver
- Study coordinator: Resendiz, Marino Je
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.