Investigating TET enzymes for treating blood cancers
Targeting TET DNA Dioxygenases as Therapeutic Principle in Myeloid Neoplasms
This study is looking at how certain changes in a gene called TET2 can affect blood cells and possibly lead to blood cancers, with the hope of finding new ways to prevent or treat these conditions for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10894317 on NIH RePORTER |
What this research studies
This research focuses on the role of TET enzymes in regulating DNA methylation, which is crucial for gene expression. By studying mutations in the TET2 gene, which are common in myeloid neoplasms, the research aims to identify early events that lead to blood cancers. The approach involves analyzing how these mutations affect hematopoietic stem and progenitor cells, potentially leading to new therapeutic strategies. Patients may benefit from insights into how to prevent or treat these conditions based on their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with myeloid neoplasms or those with TET2 mutations.
Not a fit: Patients with non-hematologic cancers or those without TET2 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the underlying genetic causes of myeloid neoplasms.
How similar studies have performed: Previous research has shown promising results in targeting genetic mutations in blood cancers, indicating that this approach may be effective.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Maciejewski, Jaroslaw P. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Maciejewski, Jaroslaw P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.