Investigating tau protein's impact on brain connectivity in Alzheimer's disease
Tau-induced connectome imaging markers of Alzheimer's disease
This study is looking at how a protein linked to Alzheimer's disease affects the way different parts of the brain connect with each other, which could help improve how we diagnose and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10875738 on NIH RePORTER |
What this research studies
This research focuses on understanding how tau protein, a key marker of Alzheimer's disease, affects brain connectivity. By utilizing advanced imaging techniques, the study aims to identify specific fiber pathways in the brain that are impacted by tau pathology. Researchers will analyze existing datasets from notable studies to explore when and where these changes occur during the progression of Alzheimer's. This could lead to better diagnostic tools and treatment strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and monitoring Alzheimer's disease progression.
How similar studies have performed: Previous research has shown promising results in using imaging techniques to study tau pathology, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Shi, Yonggang — University of Southern California
- Study coordinator: Shi, Yonggang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.