Investigating tau biomarkers in older adults with late-onset psychosis
Official title: Tau biomarkers in late-onset psychosis
Funded at Feinstein Institute for Medical Research · NIH-11018639 · Data updated 2026-11-12
This study is looking at how late-onset psychosis might be connected to Alzheimer's disease by checking for certain markers in the blood and brain of older adults who have psychotic symptoms but aren't showing signs of memory problems yet.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $213,563 |
| NIH project number | 5R21MH135148-02 |
| Project ID | NIH-11018639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing psychotic symptoms without significant cognitive impairment.
✕Less likely to help
Patients with acute medical conditions or prominent mood symptoms may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between late-onset psychosis and the risk of developing Alzheimer's disease. It aims to explore whether elevated levels of tau biomarkers, which are associated with neurodegenerative conditions, can be detected in older adults experiencing psychotic symptoms without cognitive impairment. The study will utilize advanced imaging techniques and blood tests to gather data on tau pathology in this population. By identifying these biomarkers, the research hopes to shed light on the underlying mechanisms linking psychosis and dementia.
Why it matters
Potential benefit: If successful, this research could lead to earlier identification of individuals at risk for Alzheimer's disease, allowing for timely interventions.
How similar studies have gone: While the specific approach of using tau biomarkers in this context is novel, related research has shown promising results in understanding the link between psychosis and neurodegenerative diseases.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Koppel, Jeremy — Feinstein Institute for Medical Research
- Study coordinator: Koppel, Jeremy
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.