Investigating targeted therapies for NF2-associated meningiomas
NF2-Associated Meningiomas: From Omics Discovery to Targeted Therapy
This study is looking for better ways to treat meningiomas, which are brain tumors that can happen with Neurofibromatosis 2 (NF2), by using new techniques to find effective therapies for patients whose tumors aren't responding to current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10843869 on NIH RePORTER |
What this research studies
This research focuses on understanding and treating meningiomas associated with Neurofibromatosis 2 (NF2), a condition that leads to the development of tumors in the brain. The team uses advanced techniques, including CRISPR-Cas9 genome editing and drug screening, to identify potential therapeutic targets in meningioma cells. By studying human tumor cell lines and their genetic profiles, the researchers aim to discover effective systemic therapies for patients whose tumors progress despite existing treatments. The ultimate goal is to improve treatment options and outcomes for patients with NF2-related meningiomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with NF2 or those with meningiomas that have shown resistance to standard treatments.
Not a fit: Patients without a diagnosis of NF2 or those with meningiomas that are not associated with NF2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that significantly improve the management and outcomes of patients with NF2-associated meningiomas.
How similar studies have performed: Other research has shown promise in targeting similar pathways in tumor biology, indicating that this approach could yield significant advancements in treatment.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ramesh, Vijaya — Massachusetts General Hospital
- Study coordinator: Ramesh, Vijaya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.