Investigating targeted therapies for laryngopharyngeal reflux
Mechanism Guided Therapy for Laryngopharyngeal Reflux
This study is looking for ways to better treat laryngopharyngeal reflux (LPR) by finding out more about different types of patients and testing a new device that helps with swallowing, so if you have LPR, this research could help improve your care!
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11077227 on NIH RePORTER |
What this research studies
This research focuses on improving treatment for laryngopharyngeal reflux (LPR), a condition where laryngeal symptoms are caused by gastroesophageal reflux. The study aims to identify specific patient phenotypes using novel diagnostic biomarkers and to evaluate the effectiveness of a new therapeutic device designed to assist the upper esophageal sphincter. By conducting a randomized controlled trial with 78 participants, the research seeks to provide a more personalized approach to managing LPR. Additionally, it will explore the differences in oral microbiomes between patients with and without LPR.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have been diagnosed with salivary pepsin positive laryngopharyngeal reflux.
Not a fit: Patients who do not have laryngopharyngeal reflux or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients suffering from laryngopharyngeal reflux.
How similar studies have performed: Previous research has shown promise in using targeted therapies and biomarkers for similar conditions, indicating potential for success in this approach.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Yadlapati, Rena Hiren — University of California, San Diego
- Study coordinator: Yadlapati, Rena Hiren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.