Investigating targeted drug delivery to the optic nerve
Official title: Localization, safety, and efficacy of optic nerve injections
Funded at Johns Hopkins University · NIH-11159895 · Data updated 2026-11-12
This study is exploring a new way to deliver medicine directly to the optic nerve for people with optic neuropathy, which could help improve their treatment outcomes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $172,584 |
| NIH project number | 7K08EY033407-03 |
| Project ID | NIH-11159895 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with optic neuropathy or related optic nerve disorders.
✕Less likely to help
Patients with conditions unrelated to optic nerve diseases may not benefit from this research.
What this research studies
This research focuses on developing a method to deliver therapeutics directly to the optic nerve head, which could significantly improve treatment outcomes for patients with optic neuropathy. The approach involves a novel technique called SupraChoroidal-to-Optic-Nerve (SCONE) injection, aiming to enhance the precision of drug delivery to affected areas. The project is led by Dr. Bryce Chiang, who will receive mentorship from experts in ocular drug delivery and optic nerve diseases. The research will also involve clinical training in glaucoma to ensure comprehensive understanding and application of the techniques.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from vision-threatening optic nerve diseases.
How similar studies have gone: Previous research has shown promise in targeted drug delivery methods for ocular conditions, suggesting potential success for this novel approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Chiang, Bryce — Johns Hopkins University
- Study coordinator: Chiang, Bryce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.