Investigating T follicular regulatory cells as new targets for cancer treatment
Official title: Evaluation of T follicular regulatory cells as novel cellular targets of cancer immunotherapy
Funded at University of Tx Md Anderson Can Ctr · NIH-10874575 · Data updated 2026-11-12
This study is looking at how certain immune cells called T follicular regulatory (TFR) cells affect how well cancer treatments work, with the goal of finding new ways to make these treatments more effective and easier on patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $230,407 |
| NIH project number | 5R37CA276779-03 |
| Project ID | NIH-10874575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors who are currently undergoing or considering immunotherapy treatments.
✕Less likely to help
Patients with cancers that do not involve T follicular regulatory cells or those not receiving immunotherapy may not benefit from this research.
What this research studies
This research focuses on understanding how T follicular regulatory (TFR) cells influence the effectiveness of cancer immunotherapy. By examining the role of these cells in tumor environments, the study aims to identify new therapeutic targets that could improve patient responses to existing treatments. The approach involves analyzing the presence and function of TFR cells in various cancers, which may lead to the development of more effective immunotherapy strategies with fewer side effects. Patients may benefit from insights that could enhance treatment options and outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments with improved patient responses and reduced side effects.
How similar studies have gone: Previous research has shown promise in targeting immune cells for cancer treatment, suggesting that this approach could lead to significant advancements in immunotherapy.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Eschweiler, Simon — University of Tx Md Anderson Can Ctr
- Study coordinator: Eschweiler, Simon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.