Investigating T cell immunity to cytomegalovirus in newborns and young children
T cell immunity to CMV in utero and in early childhood
This study is looking at how the immune system reacts to cytomegalovirus (CMV) infections in moms and their babies, by checking blood samples over time to see how certain immune cells develop, which could help us find better ways to handle CMV in infants.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11012897 on NIH RePORTER |
What this research studies
This research focuses on understanding how the immune system responds to cytomegalovirus (CMV) infections that occur during pregnancy and early childhood. By studying a large group of mother-infant pairs, the researchers will analyze blood samples over time to observe how T cells, particularly CD8 T cells, develop and function in response to CMV. The goal is to uncover the mechanisms behind the immune response and how it matures with age, which could provide insights into better managing CMV infections in infants.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants who were infected with CMV either in utero or during early childhood.
Not a fit: Patients who are adults or those who have not been infected with CMV may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating CMV-related complications in infants.
How similar studies have performed: Previous studies have shown promising results in understanding T cell responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Feeney, Margaret E — University of California, San Francisco
- Study coordinator: Feeney, Margaret E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.