Investigating synaptic decline in Alzheimer's disease models
Official title: Imaging Synaptic Decline in Models of Alzheimer's Disease
Funded at University of Illinois at Chicago · NIH-11081724 · Data updated 2026-11-12
This study is looking at how early changes in brain connections affect memory in Alzheimer's disease, using special imaging techniques in animal models, to help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $152,277 |
| NIH project number | 5K25AG086674-02 |
| Project ID | NIH-11081724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
✕Less likely to help
Patients with advanced Alzheimer's disease or other forms of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the early loss of synaptic function in Alzheimer's disease, which is crucial for cognitive processes like memory. By utilizing advanced imaging techniques, the study aims to observe how synaptic transmission and presynaptic signaling are affected in animal models that mimic human Alzheimer's conditions. The research will involve training and mentorship to enhance the investigator's skills in this area, ultimately aiming to uncover the mechanisms behind synaptic decline. This could lead to better insights into the disease's progression and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for Alzheimer's disease, enhancing the quality of life for patients.
How similar studies have gone: Previous research has shown promising results in understanding synaptic decline in Alzheimer's models, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Potcoava, Mariana Camelia — University of Illinois at Chicago
- Study coordinator: Potcoava, Mariana Camelia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.