Investigating sugar modifications in specific protein domains
Official title: O-glycosylation of cysteine-rich modules
Funded at University of Georgia · NIH-10986077 · Data updated 2026-11-12
This study is looking at how certain sugars change proteins that are important for how our cells communicate and work, which could help us understand genetic disorders caused by problems with these sugars.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | January 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $394,110 |
| NIH project number | 5R35GM148433-03 |
| Project ID | NIH-10986077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders linked to mutations in the enzymes involved in O-glycosylation.
✕Less likely to help
Patients without genetic disorders or those not affected by the specific enzyme mutations being studied may not benefit from this research.
What this research studies
This research focuses on understanding how certain sugars, known as O-glycans, modify proteins that play crucial roles in cell signaling and function. By examining the structures and functions of these sugars linked to Epidermal Growth Factor-like Repeats (EGFs) and Thrombospondin Type 1 Repeats (TSRs), the research aims to uncover their biological significance. The team will utilize advanced techniques to identify which proteins are modified by these sugars and how these modifications affect their function. This work is particularly important as mutations in the enzymes responsible for these modifications can lead to genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic disorders related to protein modifications, potentially paving the way for novel therapeutic strategies.
How similar studies have gone: While the specific approach of this research may be novel, similar studies have successfully identified the roles of protein modifications in various biological processes.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Haltiwanger, Robert S. — University of Georgia
- Study coordinator: Haltiwanger, Robert S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.