Investigating stress and immune responses in aging and mood disorders.
Leadership Administrative Core
This study is looking at how stress and immune system changes from pregnancy can influence mood and lead to depression in older adults, and it aims to find better treatments by understanding how these factors differ between men and women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10766720 on NIH RePORTER |
What this research studies
This research focuses on understanding how stress and immune system abnormalities, starting from fetal development, affect mood regulation and contribute to recurrent major depressive disorder (MDD) in older adults. By examining sex differences in brain circuitry and hormonal responses, the study aims to develop targeted therapies that consider these differences. The project involves collaboration among various scientific disciplines to enhance knowledge and training regarding these issues, ultimately translating findings into practical applications for patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing mood disorders, particularly those with a history of recurrent major depressive disorder.
Not a fit: Patients who are not experiencing mood disorders or are younger than the targeted age group may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, sex-specific treatments for mood disorders in older adults.
How similar studies have performed: Previous research has shown promise in understanding sex differences in mood disorders, indicating that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Goldstein, Jill M — Massachusetts General Hospital
- Study coordinator: Goldstein, Jill M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.