Investigating stem cell therapies for treating Alzheimer's disease using advanced imaging techniques in mice.
Official title: Studying stem cell-based therapies by applying advanced in vivo physiological and imaging methods to transplanted human neural populations in mice
Funded at University of Rochester · NIH-10978252 · Data updated 2026-11-12
This study is exploring how special brain cells made from stem cells can help treat Alzheimer's disease by replacing lost neurons, and it aims to see how these cells grow and connect in the brain using mice to find better ways to help people with Alzheimer's and similar conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $582,246 |
| NIH project number | 1R01NS134722-01A1 |
| Project ID | NIH-10978252 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease.
✕Less likely to help
Patients with non-neurodegenerative conditions or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on the use of human Neural Precursor Cells (hNPCs) derived from human induced Pluripotent Stem Cells (hiPSCs) to treat Alzheimer's disease by replacing lost neurons. The study aims to understand how these transplanted cells behave in the brain, including their growth, movement, and integration into existing neural circuits. By employing advanced in vivo imaging and neurophysiology methods, researchers will track the changes in these cells over time in a mouse model, providing insights into the effectiveness of stem cell therapies for neurodegenerative conditions. This research could lead to improved strategies for treating Alzheimer's and similar disorders.
Why it matters
Potential benefit: If successful, this research could lead to innovative stem cell therapies that significantly improve outcomes for patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using stem cell therapies for neurological disorders, indicating potential success for this approach.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Padmanabhan, Krishnan — University of Rochester
- Study coordinator: Padmanabhan, Krishnan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.