Investigating stem cell-like B cells and their role in cancer development
Official title: Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis
Funded at Weill Medical Coll of Cornell Univ · NIH-10873785 · Data updated 2026-11-12
This study is looking at special types of B cells that act like stem cells to see how they help B-cell lymphomas grow and come back, with the hope of finding new treatments that can better target these tough cancer cells for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $391,699 |
| NIH project number | 5R01CA283327-02 |
| Project ID | NIH-10873785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with B-cell lymphomas, particularly those who have experienced relapses.
✕Less likely to help
Patients with non-B-cell lymphomas or those who have not experienced relapses may not benefit from this research.
What this research studies
This research focuses on understanding how certain B cell subpopulations, which exhibit stem cell-like characteristics, contribute to the development and recurrence of B-cell lymphomas. By utilizing advanced techniques in single-cell analysis and epigenetics, the team aims to identify these unique B cells and their molecular features that may enhance tumor growth. The study will explore how specific mutations in lymphoma can activate these stem-like properties, potentially leading to more effective treatments for patients. Patients may benefit from insights that could lead to novel therapeutic strategies targeting these resilient cancer cells.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that prevent relapse in B-cell lymphoma patients.
How similar studies have gone: While the concept of stem-like cells in lymphomas is still being explored, preliminary studies suggest that similar approaches in other cancers have shown promise.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Apostolou, Effie — Weill Medical Coll of Cornell Univ
- Study coordinator: Apostolou, Effie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.