Investigating specific miRNAs in primate embryo and placenta development
Official title: Primate-specific miRNAs in Embryonic and Placental Development
Funded at University of Wisconsin-Madison · NIH-11010417 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in primates, especially those from a specific group on chromosome 19, help shape the growth of embryos and placentas, using rhesus macaques to see how these molecules affect the early stages of development and the important cells that support a healthy pregnancy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $248,999 |
| NIH project number | 5R00HD099154-05 |
| Project ID | NIH-11010417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with a history of placental complications during pregnancy.
✕Less likely to help
Patients who are not pregnant or do not have any known placental issues may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the role of primate-specific miRNAs, particularly those from the chromosome 19 miRNA cluster, in the development of embryos and placentas in primates. By using a rhesus macaque model, the study aims to define the expression of these miRNAs during early development and their impact on trophoblast lineage specification. The researchers will explore how these miRNAs influence the function of trophoblast stem cells and their differentiation, which is crucial for healthy placental development.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of placental pathologies that affect pregnancy outcomes.
How similar studies have gone: While the specific approach of investigating C19MC miRNAs in primate development is novel, similar studies have shown promise in understanding miRNA roles in other species.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Schmidt, Jenna Ann — University of Wisconsin-Madison
- Study coordinator: Schmidt, Jenna Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.