Investigating specific immune cells involved in brain autoimmune diseases
Official title: Defining the role of CD11c+CD88+CD317+ myeloid cells as mediators of CNS autoimmunity
Funded at VA North Texas Health Care System · NIH-10948901 · Data updated 2026-11-12
This study is looking at a special type of immune cell to see how it might play a role in autoimmune diseases that affect the brain and nervous system, with the hope of finding new ways to help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA North Texas Health Care System NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | October 1, 2021 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005664-04 |
| Project ID | NIH-10948901 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation would include individuals diagnosed with autoimmune conditions affecting the central nervous system.
✕Less likely to help
Patients with non-autoimmune neurological disorders may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of a particular type of immune cell, known as CD11c+CD88+CD317+ myeloid cells, in the development of autoimmune diseases affecting the central nervous system (CNS). By examining how these cells function and contribute to CNS autoimmunity, the research aims to uncover potential mechanisms that could lead to new treatment strategies. Patients may benefit from insights gained through this research, which could inform future therapies targeting these immune cells. The approach involves laboratory studies and analysis of immune responses in patients with CNS conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases of the central nervous system.
How similar studies have gone: While the specific role of these immune cells in CNS autoimmunity is being explored, similar research has shown promise in understanding immune mechanisms in other autoimmune diseases.
Where this research is happening
-
VA North Texas Health Care System
Dallas, United States Active
Researchers
- Principal investigator: Stuve, Olaf — VA North Texas Health Care System
- Study coordinator: Stuve, Olaf
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.