Investigating specific FGFR signaling pathways in lung disease
Targeting Isoform-specific FGFR Signaling in Idiopathic Pulmonary Fibrosis
This study is looking at how certain proteins in the lungs might affect the worsening of Idiopathic Pulmonary Fibrosis (IPF) in older adults, with the hope of finding new treatments to help those living with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11117642 on NIH RePORTER |
What this research studies
This research focuses on Idiopathic Pulmonary Fibrosis (IPF), a serious lung condition primarily affecting older adults. The study aims to understand how different forms of the fibroblast growth factor receptor (FGFR) contribute to the disease's progression. By conducting laboratory studies on lung cells and using animal models, researchers will explore how targeting specific FGFR pathways may lead to new treatment options. This approach seeks to provide insights into the disease mechanisms and develop effective therapies for patients suffering from IPF.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 65 years old who have been diagnosed with Idiopathic Pulmonary Fibrosis.
Not a fit: Patients with other forms of lung disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted treatments that effectively alleviate the symptoms and progression of Idiopathic Pulmonary Fibrosis.
How similar studies have performed: Previous research has shown promise in targeting specific signaling pathways in similar conditions, indicating potential for success in this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Lee, Sangwon — Yale University
- Study coordinator: Lee, Sangwon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.