Investigating smell and sight changes as early signs of Alzheimer's disease
Olfactory and Visual Dysfunction as Potential Predictors of Preclinical Alzheimer's Disease
This study is looking at how problems with smelling and seeing might be early signs of Alzheimer's disease in people who are at risk, like those with certain genetic factors or mild memory issues, to see if these changes can help spot the disease before it fully develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10534224 on NIH RePORTER |
What this research studies
This research explores how changes in the ability to identify odors and visual function may indicate early signs of Alzheimer's disease (AD). It focuses on individuals at risk for AD, such as those with the ApoE e4 allele or mild cognitive impairment (MCI). By using advanced testing methods beyond simple odor identification, the study aims to determine if these sensory impairments can serve as reliable indicators of preclinical AD. The research will also examine the relationship between these sensory changes and biomarkers found in cerebrospinal fluid and brain imaging.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease, those carrying the ApoE e4 allele, or individuals diagnosed with mild cognitive impairment.
Not a fit: Patients who do not have any risk factors for Alzheimer's disease or those with advanced stages of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of Alzheimer's disease, allowing for timely interventions and better management of the condition.
How similar studies have performed: Previous research has shown that sensory impairments can be indicative of Alzheimer's disease, but this study aims to refine and validate these findings through a novel multimodal approach.
Where this research is happening
San Diego, United States
- San Diego State University — San Diego, United States (Active)
Researchers
- Principal investigator: Murphy, Claire L — San Diego State University
- Study coordinator: Murphy, Claire L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.