Investigating small RNAs in the spread of breast cancer
Small RNAs in Breast Cancer Metastasis
This study is looking at how tiny molecules called small RNAs affect the spread of breast cancer, especially in cases that are positive for estrogen receptors, and it hopes to find new ways to treat the disease by examining changes in cancer cells from patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10673685 on NIH RePORTER |
What this research studies
This research focuses on understanding how small RNAs influence the metastasis of breast cancer, particularly in estrogen receptor-positive cases. It aims to explore the role of the MED1 coactivator, which is linked to both resistance to common treatments like tamoxifen and the aggressive spread of cancer to other organs. By analyzing genetic changes and mutations in circulating tumor cells, the study seeks to uncover the molecular mechanisms that drive these processes. Patients may be involved in providing samples or data to help identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with estrogen receptor-positive breast cancer, especially those experiencing treatment resistance or metastasis.
Not a fit: Patients with non-estrogen receptor-positive breast cancer or those who are not currently undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for breast cancer patients, particularly those whose tumors are resistant to current therapies.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways in breast cancer, suggesting potential for success in this approach.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Zhang, Xiaoting — University of Cincinnati
- Study coordinator: Zhang, Xiaoting
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.