Investigating small nucleolar RNAs in blood plasma of Alzheimer's patients as potential biomarkers
ncRNAs in plasma EVs of AD patients and their discriminatory power as biomarkers
This study is looking at tiny molecules in the blood of people with Alzheimer's disease to see if they can help doctors diagnose the condition earlier and track how it changes over time, making it easier for patients to get the care they need.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10532000 on NIH RePORTER |
What this research studies
This research focuses on identifying small nucleolar RNAs (snoRNAs) found in plasma extracellular vesicles (EVs) of patients with Alzheimer's disease (AD). By analyzing these molecules, the study aims to determine their potential as biomarkers for early diagnosis and monitoring of AD progression. The researchers will use advanced detection technology to measure the levels of specific snoRNAs in blood samples, comparing them between AD patients and healthy individuals. This approach could provide a non-invasive method for assessing Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing cognitive decline.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of Alzheimer's disease, improving patient management and treatment outcomes.
How similar studies have performed: Previous research has shown promise in using biomarkers for Alzheimer's diagnosis, but the specific approach of using snoRNAs in plasma EVs is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Lefterov, Iliya — University of Pittsburgh at Pittsburgh
- Study coordinator: Lefterov, Iliya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.