Investigating small molecules that mimic Humanin to treat Alzheimer's disease
Small molecule mimetics of Humanin that normalize neuronal p-Akt as novel therapeutics for AD
This study is looking for new tiny drugs that can help protect brain cells in people with Alzheimer's disease by mimicking a natural protein called Humanin, which may help keep those cells healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11079669 on NIH RePORTER |
What this research studies
This research focuses on developing small molecules that mimic the Humanin peptide, which has shown potential in enhancing neuronal health by normalizing levels of phospho-Akt, a protein important for cell survival. The approach involves optimizing these molecules for better potency and brain permeability, and testing their effectiveness in models of Alzheimer's disease. By screening various compounds, the researchers aim to identify those that can protect neurons from damage associated with Alzheimer's, potentially leading to new therapeutic options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that protect neurons and improve outcomes for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using peptide mimetics for neuroprotection, suggesting a potential for success with this novel approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: John, Varghese — University of California Los Angeles
- Study coordinator: John, Varghese
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.