Investigating small molecules that inhibit cancer cell migration
Assessment of small molecules as covalent inhibitors of Rac/Cdc42
This study is testing a new medicine called CPV-337 to see if it can help stop cancer cells from spreading in people with metastatic breast cancer, building on earlier promising results from another medicine called MBQ-167.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project ID | NIH-11056076 on NIH RePORTER |
What this research studies
This research focuses on developing small molecule inhibitors that target specific proteins involved in cancer cell migration, which is a key factor in the spread of cancer. The team has previously created a compound called MBQ-167, which has shown promise in reducing tumor growth and metastasis in animal models. They are now exploring a new, more potent inhibitor, CPV-337, to further enhance its effectiveness against cancer cells. The research involves both laboratory experiments and pre-clinical trials to assess the safety and efficacy of these compounds in treating metastatic breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic breast cancer who are seeking new treatment options.
Not a fit: Patients with early-stage breast cancer or those not diagnosed with breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with metastatic breast cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown success with similar small molecule inhibitors in reducing cancer metastasis, indicating a promising avenue for further exploration.
Where this research is happening
San Juan, United States
- University of Puerto Rico Med Sciences — San Juan, United States (Active)
Researchers
- Principal investigator: Vlaar, Cornelis P — University of Puerto Rico Med Sciences
- Study coordinator: Vlaar, Cornelis P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.