Investigating small molecules that affect MYC proteins in cancer
Small molecule probes of MYC stability and function intumorigenesis
This study is working on creating new medicines that can help fight certain cancers by targeting a protein called MYC, which helps cancer cells grow; the goal is to find ways to make these cancer cells weaker and improve treatment for patients with MYC-related tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11042842 on NIH RePORTER |
What this research studies
This research focuses on developing small molecule inhibitors that target MYC oncoproteins, which are crucial for the survival and growth of various cancers. By using advanced computer modeling and in vivo screening, the researchers aim to create compounds that can disrupt MYC's function and promote its degradation. This approach could lead to significant changes in how cancer cells behave, potentially improving treatment outcomes for patients with MYC-driven tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancers driven by MYC oncoproteins, such as c-MYC, L-MYC, or N-MYC.
Not a fit: Patients with cancers not associated with MYC oncoproteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce tumor growth and improve survival rates for patients with MYC-related cancers.
How similar studies have performed: Other research has shown promise in targeting MYC proteins with small molecules, indicating that this approach has potential for success.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Abdulkadir, Sarki a. — Northwestern University at Chicago
- Study coordinator: Abdulkadir, Sarki a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.